Recurrent Goodpasture's disease due to a monoclonal IgA-kappa circulating antibody

被引：40

作者：

Fervenza, FC

Terreros, D

Boutaud, A

Hudson, BG

Williams, RA

Donadio, JV

Schwab, TR

机构：

[1] Mayo Clin & Mayo Grad Sch Med, Div Nephrol, Rochester, MN 55905 USA

[2] Univ Utah, Dept Pathol, Salt Lake City, UT USA

[3] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66103 USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1999年 / 34卷 / 03期

关键词：

immunoglobulin A (IgA) monoclonal gammopathy; pulmonary hemorrhage; IgA nephropathy; glomerulonephritis; anti-glomerular basement membrane antibody disease; Goodpasture's syndrome;

D O I：

10.1016/S0272-6386(99)70084-3

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the case of a 54-year-old man who first presented with a clinical syndrome manifested by recurrent pulmonary hemorrhage, hematuria, and mild renal insufficiency, Direct immunofluorescence of renal biopsy sections showed linear deposition of IgA-kappa in the glomerular (GBM) and tubular basement membranes, Serum protein immunoelectrophoresis was positive for a monoclonal immunoglobulin A (IgA)-kappa protein, Serum analysis showed circulating IgA anti-GBM antibodies, Treatment with high-dose steroids, cyclophosphamide, and plasma exchange resulted in resolution of the clinical picture, To the best of our knowledge, this is the first report of Goodpasture's disease associated with the presence of a circulating monoclonal IgA-kappa antibody. (C) 1999 by the National Kidney Foundation, Inc.

引用

页码：549 / 555

页数：7

共 26 条

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