Meningococcal interactions with the host

被引:70
作者
Carbonnelle, Etienne [2 ]
Hill, Darryl J. [1 ]
Morand, Philippe [2 ]
Griffiths, Natalie J. [1 ]
Bourdoulous, Sandrine [3 ]
Murillo, Isabel [1 ]
Nassif, Xavier [2 ]
Virji, Mumtaz [1 ]
机构
[1] Univ Bristol, Univ Walk, Sch Med Sci, Dept Cellular & Mol Med, Bristol BS8 1TD, Avon, England
[2] Univ Paris 05, Fac Med, INSERM, U570, F-75015 Paris, France
[3] Univ Paris 05, CNRS, INSERM, Dept Biol Cellulaire,Inst Cochin,UMR8104,U567, F-75014 Paris, France
基金
英国医学研究理事会;
关键词
Adhesion; Receptors; Pathogenic mechanisms; OUTER-MEMBRANE PROTEIN; HUMAN ENDOTHELIAL-CELLS; IV PILUS BIOGENESIS; IMMUNOGENIC AUTOTRANSPORTER PROTEIN; TRANSMISSION ELECTRON-MICROSCOPY; 2-PARTNER SECRETION SYSTEM; MENINGITIDIS SEROGROUP-B; HUMAN EPITHELIAL-CELLS; BLOOD-BRAIN-BARRIER; NEISSERIA-MENINGITIDIS;
D O I
10.1016/j.vaccine.2009.04.069
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins: many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:B78 / B89
页数:12
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