A late wave of melanoblast differentiation and rostrocaudal migration revealed in patch and rump-white embryos

被引：27

作者：

Jordan, SF ^{[1
]}

Jackson, IJ ^{[1
]}

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 92卷 / 02期

基金：

英国医学研究理事会;

关键词：

mouse; patch; rump-white; Dct; Kit; Mgf; melanoblast; melanocyte; neural crest; pigmentation; transgene;

D O I：

10.1016/S0925-4773(99)00332-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Melanocytes originate from a small number of precursors localized either side of the dorsal midline. The tyrosine kinase receptor Kit and its ligand Mgf (Steel Factor) are essential for melanoblast survival and proliferation during their migration from the neural crest. Inappropriate Kit expression in the dermatome and dermis of patch and rump-white mouse mutants apparently sequester Mgf, inhibiting melanoblast dispersal. Using a reporter transgene Dct-lacZ extensive regions of the mutant trunks appear devoid of melanoblasts between E12.5 and E15.5, a much larger area than seen in mutant adults. Melanoblast recolonization of the underpopulated lumbar regions occurs very rapidly by E16.5 giving rise to patterns consistent with those observed in adults. The mutations permit observation of aspects of melanoblast development that are not seen, or are obscured, in normal embryos. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 143

页数：9

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