A late wave of melanoblast differentiation and rostrocaudal migration revealed in patch and rump-white embryos

被引：26

作者：

Jordan, SF ^{[1
]}

Jackson, IJ ^{[1
]}

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 92卷 / 02期

基金：

英国医学研究理事会;

关键词：

mouse; patch; rump-white; Dct; Kit; Mgf; melanoblast; melanocyte; neural crest; pigmentation; transgene;

D O I：

10.1016/S0925-4773(99)00332-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Melanocytes originate from a small number of precursors localized either side of the dorsal midline. The tyrosine kinase receptor Kit and its ligand Mgf (Steel Factor) are essential for melanoblast survival and proliferation during their migration from the neural crest. Inappropriate Kit expression in the dermatome and dermis of patch and rump-white mouse mutants apparently sequester Mgf, inhibiting melanoblast dispersal. Using a reporter transgene Dct-lacZ extensive regions of the mutant trunks appear devoid of melanoblasts between E12.5 and E15.5, a much larger area than seen in mutant adults. Melanoblast recolonization of the underpopulated lumbar regions occurs very rapidly by E16.5 giving rise to patterns consistent with those observed in adults. The mutations permit observation of aspects of melanoblast development that are not seen, or are obscured, in normal embryos. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 143

页数：9

共 40 条

[21] MOSAIC EXPRESSION OF A TYROSINASE FUSION GENE IN ALBINO MICE YIELDS A HERITABLE STRIPED COAT COLOR PATTERN IN TRANSGENIC HOMOZYGOTES [J].

MINTZ, B ;

BRADL, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9643-9647

[22] TRANSIENT STEEL FACTOR DEPENDENCE BY NEURAL CREST-DERIVED MELANOCYTE PRECURSORS [J].

MORRISONGRAHAM, K ;

WESTON, JA .

DEVELOPMENTAL BIOLOGY, 1993, 159 (01) :346-352

[23] STEEL FACTOR IS REQUIRED FOR MAINTENANCE, BUT NOT DIFFERENTIATION, OF MELANOCYTE PRECURSORS IN THE NEURAL CREST [J].

MURPHY, M ;

REID, K ;

WILLIAMS, DE ;

LYMAN, SD ;

BARTLETT, PF .

DEVELOPMENTAL BIOLOGY, 1992, 153 (02) :396-401

[24] STRUCTURAL-ANALYSIS OF CHROMOSOMAL REARRANGEMENTS ASSOCIATED WITH THE DEVELOPMENTAL MUTATIONS PH, W-19H, AND RW ON MOUSE CHROMOSOME-5 [J].

NAGLE, DL ;

MARTINDELEON, P ;

HOUGH, RB ;

BUCAN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :7237-7241

[25] PHYSICAL MAPPING OF THE TEC AND GABRB1 LOCI REVEALS THAT THE W-SH MUTATION ON MOUSE CHROMOSOME-5 IS ASSOCIATED WITH AN INVERSION [J].

NAGLE, DL ;

KOZAK, CA ;

MANO, H ;

CHAPMAN, VM ;

BUCAN, M .

HUMAN MOLECULAR GENETICS, 1995, 4 (11) :2073-2079

[26] INUTERO MANIPULATION OF COAT COLOR FORMATION BY A MONOCLONAL ANTI-C-KIT ANTIBODY - 2 DISTINCT WAVES OF C-KIT-DEPENDENCY DURING MELANOCYTE DEVELOPMENT [J].

NISHIKAWA, S ;

KUSAKABE, M ;

YOSHINAGA, K ;

OGAWA, M ;

HAYASHI, SI ;

KUNISADA, T ;

ERA, T ;

SAKAKURA, T ;

NISHIKAWA, SI .

EMBO JOURNAL, 1991, 10 (08) :2111-2118

[27] MOLECULAR-BASES OF DOMINANT NEGATIVE AND LOSS OF FUNCTION MUTATIONS AT THE MURINE C-KIT WHITE SPOTTING LOCUS - W37, WV, W41 AND W [J].

NOCKA, K ;

TAN, JC ;

CHIU, E ;

CHU, TY ;

RAY, P ;

TRAKTMAN, P ;

BESMER, P .

EMBO JOURNAL, 1990, 9 (06) :1805-1813

[28]

Parichy DM, 1999, DEVELOPMENT, V126, P3425

[29] ORIGIN OF PIGMENT CELLS FROM THE NEURAL CREST IN THE MOUSE EMBRYO [J].

RAWLES, ME .

PHYSIOLOGICAL ZOOLOGY, 1947, 20 (03) :248-265

[30] STEEL FACTOR DIRECTS MELANOCYTE DEVELOPMENT IN-VITRO THROUGH SELECTIVE REGULATION OF THE NUMBER OF C-KIT(+) PROGENITORS [J].

REID, K ;

NISHIKAWA, SI ;

BARTLETT, PF ;

MURPHY, M .

DEVELOPMENTAL BIOLOGY, 1995, 169 (02) :568-579

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