Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice

被引：372

作者：

Picard-Riera, N ^{[1
]}

Decker, L ^{[1
]}

Delarasse, C ^{[1
]}

Goude, K ^{[1
]}

Nait-Oumesmar, B ^{[1
]}

Liblau, R ^{[1
]}

Pham-Dinh, D ^{[1
]}

Baron-Van Evercooren, A ^{[1
]}

机构：

[1] CHU Pitie Salpetriere, Inst Federat Rech Neurosci, Lab Affect Myeline & Canaux Ion, INSERM U546, F-75634 Paris 13, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 20期

关键词：

D O I：

10.1073/pnas.192314199

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The destiny of the mitotically active cells of the subventricular zone (SVZ) in adult rodents is to migrate to the olfactory bulb, where they contribute to the replacement of granular and periglomerular neurons. However, these adult neural progenitors also can be mobilized in periventricular white matter and triggered to differentiate into astrocytes and oligodendrocytes in response to lysolecithin-induced demyelination. To mimic the environmental conditions of multiple sclerosis, we assessed the proliferation, migration, and differentiation potential of adult SVZ progenitor cells in response to experimental autoimmune encephalomyelitis (EAE) in mice. Inflammation and demyelination were observed in all mouse brains after EAE induction. EAE induced cell proliferation throughout the brain and especially within the lesions. Proliferating cells were neural progenitors, astrocytes, and oligodendrocyte precursors. EAE enhanced the migration of SVZ-derived neural progenitors to the olfactory bulb and triggered their mobilization in the periventricular white matter. The mobilized cells gave rise to neurons, astrocytes, and oligodendrocytes in the olfactory bulb but essentially to astrocytes and oligodendrocytes in the lesioned white matter. Our data indicate that the adult mouse SVZ is a source of newly generated oligodendrocytes and thus may contribute, along with oligodendrocyte precursors, to the replacement of oligodendrocytes in inflammatory demyelinating diseases of the central nervous system such as multiple sclerosis.

引用

页码：13211 / 13216

页数：6

共 39 条

[21] Development of myelin oligodendrocyte glycoprotein autoreactive transgenic B lymphocytes:: Receptor editing in vivo after encounter of a self-antigen distinct from myelin oligodendrocyte glycoprotein [J].