The prime-boost strategy: exciting prospects for improved vaccination

被引:291
作者
Ramshaw, IA [1 ]
Ramsay, AJ
机构
[1] Australian Natl Univ, John Curtin Sch Med Res, Div Cell Biol & Immunol, Canberra, ACT 2601, Australia
[2] Univ Newcastle, Fac Med, Ctr Biomol Vaccine Technol, Discipline Immunol & Microbiol, Newcastle, NSW 2300, Australia
来源
IMMUNOLOGY TODAY | 2000年 / 21卷 / 04期
关键词
D O I
10.1016/S0167-5699(00)01612-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Unprecedented levels of cell-mediated immunity can be stimulated by the consecutive use of DNA vaccines and attenuated poxvirus vectors encoding similar heterologous antigens. This may offer a means of preventive vaccination against diseases for which no effective treatment is available.
引用
收藏
页码:163 / 165
页数:3
相关论文
共 20 条
[1]  
ALLEN TM, 1999, 17 ANN S NONH PRIM M
[2]   T lymphocyte responses in HIV-1 infection: implications for vaccine development [J].
Brander, C ;
Walker, B .
CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (04) :451-459
[3]   T cell affinity maturation by selective expansion during infection [J].
Busch, DH ;
Pamer, EG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (04) :701-709
[4]   Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: Propagation and generation of recombinant viruses in a nonhuman mammalian cell line [J].
Carroll, MW ;
Moss, B .
VIROLOGY, 1997, 238 (02) :198-211
[5]   DNA vaccines [J].
Donnelly, JJ ;
Ulmer, JB ;
Shiver, JW ;
Liu, MA .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :617-648
[6]  
Excler JL, 1997, AIDS, V11, pS127
[7]   Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen [J].
Hanke, T ;
Samuel, RV ;
Blanchard, TJ ;
Neumann, VC ;
Allen, TM ;
Boyson, JE ;
Sharpe, SA ;
Cook, N ;
Smith, GL ;
Watkins, DI ;
Cranage, MP ;
McMichael, AJ .
JOURNAL OF VIROLOGY, 1999, 73 (09) :7524-7532
[8]   Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus [J].
Kent, SJ ;
Zhao, A ;
Best, SJ ;
Chandler, JD ;
Boyle, DB ;
Ramshaw, IA .
JOURNAL OF VIROLOGY, 1998, 72 (12) :10180-10188
[9]  
LEONG KH, 1995, VACCINES, P327
[10]   Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA pins protein vaccination [J].
Letvin, NL ;
Montefiori, DC ;
Yasutomi, Y ;
Perry, HC ;
Davies, ME ;
Lekutis, C ;
Alroy, M ;
Freed, DC ;
Lord, CI ;
Handt, LK ;
Liu, MA ;
Shiver, JW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9378-9383