Amphidinolide V, novel 14-membered macrolide from marine dinoflagellate Amphidinium sp.

被引：24

作者：

Kubota, T ^{[1
]}

Tsuda, M ^{[1
]}

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期

关键词：

marine dinoflagellate; macrolide; polyene; cytotoxic;

D O I：

10.1016/S0040-4039(99)02170-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel 14-membered polyene macrolide, amphidinolide V (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated by spectroscopic data. The relative stereochemistry of C-8, C-9, C-10, and C-13 was elucidated by NOESY correlations. Amphidinolide V (1) possessing five exo-methylenes and one epoxide exhibited cytotoxicity against tumor cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：713 / 716

页数：4

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