The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

被引：22

作者：

Xu, WM

Liu, LZ

Emson, P

Harrington, CR

McKeith, IG

Perry, RH

Morris, CM

Charles, IG

机构：

[1] Wolfson Inst Biomed Res, London WC1E 6AU, England

[2] Babraham Inst, Dept Neurobiol, Cambridge CB2 2QH, England

[3] MRC Ctr, Cambridge Brain Bank Lab, Cambridge CB2 2QH, England

[4] Univ Aberdeen, Dept Mental Hlth, Aberdeen AB25 2ZD, Scotland

[5] Newcastle Gen Hosp, MRC, Neurochem Pathol Unit, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

NEUROREPORT | 2000年 / 11卷 / 02期

关键词：

CCTTT repeat; DLB; NOS2A promoter polymorphism;

D O I：

10.1097/00001756-200002070-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：297 / 299

页数：3

共 15 条

[1] Rate and severity of HIV-associated dementia (HAD): Correlations with Gp41 and iNOS [J].