(S)-(+)-Ibuprofen-based hydrogelators:: an approach toward anti-inflammatory drug delivery

被引：71

作者：

Bhuniya, Sankarprasad ^{[1
]}

Seo, Young Jun ^{[1
]}

Kim, Byeang Hyean ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Natl Res Lab, Dept Chem, BK Sch Mol Sci, Pohang 790784, South Korea

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 40期

关键词：

hydrogelator; anti-inflammatory; self-delivery;

D O I：

10.1016/j.tetlet.2006.08.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have synthesized (S)-(+)-ibuprofen-based hydrogelators that feature dipeptide linkages. In aqueous media, one of these hydrogelators formed robust gels that were stable for several months. Enzyme-mediated hydrolysis offers a route toward the sustained release of this anti-inflammatory agent. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：7153 / 7156

页数：4

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