Splicing regulation in neurologic disease

被引：203

作者：

Licatalosi, Donny D.

Darnell, Robert B.

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

[2] Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10021 USA

来源：

NEURON | 2006年 / 52卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2006.09.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The importance of alternative splicing in the regulation of diverse biological processes is reflected in the growing list of human diseases associated with known or suspected splicing defects. It is becoming evident that alternative splicing plays a particularly important role in neurologic disease, which is perhaps not surprising given the important role splicing plays in generating complexity and function in the brain. This review considers the evidence that defects in regulation of splicing may underlie many types of human neurologic diseases.

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收藏

页码：93 / 101

页数：9

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