Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia

被引：60

作者：

Hatanpaa, KJ

Blass, DM

Pletnikova, O

Crain, BJ

Bigio, EH

Hedreen, JC

White, CL

Troncoso, JC

机构：

[1] Univ Texas, SW Med Sch, Dept Pathol, Dallas, TX 75390 USA

[2] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

NEUROLOGY | 2004年 / 63卷 / 03期

关键词：

D O I：

10.1212/01.WNL.0000129543.46734.C0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.

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页码：538 / 542

页数：5

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