Apolipoprotein E structure: insights into function

被引：450

作者：

Hatters, Danny M.

Peters-Libeu, Clare A.

Weisgraber, Karl H. ^{[1
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 08期

关键词：

D O I：

10.1016/j.tibs.2006.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins. Through its interaction with members of the low-density lipoprotein receptor family, apoE has a key role in lipid transport both in the plasma and in the central nervous system. Its three common structural isoforms differentially affect the risk of developing atherosclerosis and neuro-degenerative disorders, including Alzheimer's disease. Because the function of apoE is dictated by its structure, understanding the structural properties of apoE and its isoforms is required both to determine its role in disease and for the development of therapeutic strategies.

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收藏

页码：445 / 454

页数：10

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