The potential role of gene therapy in the treatment of bladder cancer

被引：18

作者：

Hsieh, JT

Dinney, CPN

Chung, LWK

机构：

[1] Univ Texas, SW Med Ctr, Dept Urol, Dallas, TX 75235 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA

[3] Univ Virginia, Dept Urol, Mol Urol & Therapeut Program, Charlottesville, VA USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2000年 / 27卷 / 01期

关键词：

D O I：

10.1016/S0094-0143(05)70238-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Based on understanding the molecular mechanism of bladder carcinogenesis, cancer gene therapy may well become a novel therapy in the near future. Currently, a viral vector system appears to be a better vehicle to deliver genes into target cells. Exploring different therapeutic strategies has generated promising results from preclinical bladder cancer models. Phase I clinical trials are underway to study the feasibility of this treatment for human bladder cancer patients. However, several potential problems associated with effective gene delivery need to be further refined.

引用

页码：103 / +

页数：12

共 84 条

[81] Adenoviral-p53 gene transfer to orthotopic and peritoneal murine bladder cancer [J].