STIMulating store-operated Ca2+ entry

被引：341

作者：

Cahalan, Michael D. ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Inst Immunol, Irvine, CA 92697 USA

来源：

NATURE CELL BIOLOGY | 2009年 / 11卷 / 06期

关键词：

STROMAL INTERACTION MOLECULE-1; CALCIUM SENSOR STIM1; CA2+-SELECTIVE ARC CHANNELS; PLASMA MEMBRANE JUNCTIONS; ACTIVATES CRAC CHANNELS; SMOOTH-MUSCLE-CELLS; CURRENT I-CRAC; ENDOPLASMIC-RETICULUM; TRPC CHANNELS; NEOINTIMA FORMATION;

D O I：

10.1038/ncb0609-669

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium influx through plasma membrane store-operated Ca2+ (SOC) channels is triggered when the endoplasmic reticulum (ER) Ca2+ store is depleted - a homeostatic Ca2+ signalling mechanism that remained enigmatic for more than two decades. RNA-interference (RNAi) screening and molecular and cellular physiological analysis recently identified STIM1 as the mechanistic 'missing link' between the ER and the plasma membrane. STIM proteins sense the depletion of Ca2+ from the ER, oligomerize, translocate to junctions adjacent to the plasma membrane, organize Orai or TRPC (transient receptor potential cation) channels into clusters and open these channels to bring about SOC entry.

引用

页码：669 / 677

页数：9

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