Chromatin-based silencing mechanisms

被引：68

作者：

Bender, J ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Biochem & Mol Biol, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2004年 / 7卷 / 05期

关键词：

D O I：

10.1016/j.pbi.2004.07.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eukaryotic genomes are organized into regions of transcriptionally active euchromatin and transcriptionally inactive heterochromatin. In plant genomes, heterochromatin is marked by methylation of cytosine and methylation of histone H3 at lysine 9. Heterochromatin formation is targeted to transposons as a means of defending the host genome against the deleterious effects of these sequences. Heterochromatin is directed to transposon sequences by transposon-derived aberrant RNA species and functions to prevent unwanted transcription and movement. Formation of heterochromatin at rRNA-encoding genes and centromere-associated repeats might also involve an RNA-based mechanism that is designed to stabilize these potentially labile structures.

引用

页码：521 / 526

页数：6

共 47 条

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