The role of the ZEB family of transcription factors in development and disease

被引：425

作者：

Vandewalle, C. ^{[1
,2
]}

Van Roy, F. ^{[2
,3
]}

Berx, G. ^{[1
,2
]}

机构：

[1] Univ Ghent VIB, Unit Mol & Cellular Oncol, Dept Mol Biomed Res, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Mol Biol, B-9052 Ghent, Belgium

[3] Univ Ghent VIB, Mol Cell Biol Unit, Dept Mol Biomed Res, B-9052 Ghent, Belgium

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 05期

关键词：

EMT; ZEB; development; cancer; invasion; transcription; migration; SMAD-INTERACTING PROTEIN-1; EPITHELIAL-MESENCHYMAL TRANSITION; E-CADHERIN EXPRESSION; FINGER-HOMEODOMAIN PROTEIN; MOWAT-WILSON-SYNDROME; SYNDROMIC HIRSCHSPRUNG-DISEASE; MENTAL RETARDATION SYNDROME; LOBULAR BREAST CANCERS; REPRESSES E-CADHERIN; NF-KAPPA-B;

D O I：

10.1007/s00018-008-8465-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ZEB family of zinc finger transcription factors are essential players during normal embryonic development. One characteristic is that they induce epithelial to mesenchymal transition (EMT), a process that reorganizes epithelial cells to become migratory mesenchymal cells. E-cadherin is a major target gene of these transcriptional repressors, and this downregulation is considered a hallmark of EMT. In recent years, the involvement of the ZEB proteins in pathological contexts has been documented as well. Mutations in ZEB encoding genes cause severe syndromic malformations and evidence is mounting that links these factors to malignant tumor progression. In this review, we describe what is currently known on the molecular pathways these transcription factors are implicated in, and we highlight their roles in development and human diseases, with a focus on tumor malignancy.

引用

页码：773 / 787

页数：15

共 116 条

[81] Defective binding of transcriptional repressor ZEB via DNA methylation contributes to increased constitutive levels of p73 in Fanconi anemia cells [J].