The epidemiology of Plasmodium falciparum gametocytes:: weapons of mass dispersion

被引:149
作者
Drakeley, Chris
Sutherland, Colin
Bouserna, J. Teun
Sauerwein, Robert W.
Targett, Geoffrey A. T.
机构
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[2] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands
基金
英国惠康基金;
关键词
D O I
10.1016/j.pt.2006.07.001
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Much of the epidemiology of Plasmodium falciparum in Sub-Saharan Africa focuses on the prevalence patterns of asexual parasites in people of different ages, whereas the gametocytes that propagate the disease are often neglected. One expected benefit of the widespread introduction of artemisinin-based combination therapy for malaria is a reduction in gametocyte carriage. However, the factors that affect the transmission of parasites from humans to mosquitoes show complex dynamics in relation to the intensity and seasonality of malaria transmission, and thus such benefits might not be automatic. Here, we review data on gametocyte carriage in the context of the development of naturally acquired immunity and population infectivity.
引用
收藏
页码:424 / 430
页数:7
相关论文
共 73 条
[1]   Dynamics of gametocytes among Plasmodium falciparum clones in natural infections in an area of highly seasonal transmission [J].
Abdel-Wahab, A ;
Abdel-Muhsin, AMA ;
Ali, E ;
Suleiman, S ;
Ahmed, S ;
Walliker, D ;
Babiker, HA .
JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (12) :1838-1842
[2]   CORRELATION OF PLASMODIUM-FALCIPARUM GAMETOCYTEMIA WITH COMPLEMENT COMPONENT TITERS IN RURAL NIGERIAN SCHOOL-CHILDREN [J].
ADESERRANO, MA ;
EJEZIE, GC ;
KASSIM, OO .
JOURNAL OF CLINICAL MICROBIOLOGY, 1981, 13 (01) :195-198
[3]  
Adjuik M, 2004, LANCET, V363, P9, DOI 10.1016/S0140-6736(03)15162-8
[4]   Dynamics of P-falciparum gametocytemia in symptomatic patients in an area of intense perennial transmission in Tanzania [J].
Akim, NIJ ;
Drakeley, C ;
Kingo, T ;
Simon, B ;
Senkoro, K ;
Sauerwein, RW .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2000, 63 (3-4) :199-203
[5]  
Alves FP, 2005, J MED ENTOMOL, V42, P777, DOI 10.1603/0022-2585(2005)042[0777:ACOPSA]2.0.CO
[6]  
2
[7]   EVIDENCE FOR SPECIFIC SUPPRESSION OF GAMETOCYTEMIA BY PLASMODIUM-FALCIPARUM IN RESIDENTS OF HYPERENDEMIC IRIAN JAYA [J].
BAIRD, JK ;
JONES, TR ;
PURNOMO ;
MASBAR, S ;
RATIWAYANTO, S ;
LEKSANA, B .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 44 (02) :183-190
[8]   Population biology and antimalarial resistance:: The transmission of antimalarial drug resistance in Plasmodium falciparum [J].
Barnes, KI ;
White, NJ .
ACTA TROPICA, 2005, 94 (03) :230-240
[9]   Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa [J].
Barnes, KI ;
Durrheim, DN ;
Little, F ;
Jackson, A ;
Mehta, U ;
Allen, E ;
Dlamini, SS ;
Tsoka, J ;
Bredenkamp, B ;
Mthembu, DJ ;
White, NJ ;
Sharp, BL .
PLOS MEDICINE, 2005, 2 (11) :1123-1134
[10]   Spreading the seeds of million-murdering death : metamorphoses of malaria in the mosquito [J].
Baton, LA ;
Ranford-Cartwright, LC .
TRENDS IN PARASITOLOGY, 2005, 21 (12) :573-580