Iridium-catalyzed enantioselective synthesis of allylic alcohols: Silanolates as hydroxide equivalents

被引：108

作者：

Lyothier, Isabelle ^{[1
]}

Defieber, Christian ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 37期

关键词：

alcohols; allylic compounds; asymmetric catalysis; iridium; nucleophilic substitution;

D O I：

10.1002/anie.200602408

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Masked hydroxide: A highly regio- and enantioselective Ir-catalyzed allylic etherification of acyclic, achiral allylic carbonates can be achieved by using potassium silanolates as nucleophiles. The use of these hydroxide equivalents allows access to valuable chiral allylic alcohols. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：6204 / 6207

页数：4

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