Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells

被引：8

作者：

Li, Li-Hua ^{[1
]}

Lu, Bin ^{[1
]}

Wu, Hong-Ke ^{[1
]}

Zhang, Hao ^{[1
]}

Yao, Fei-Fei ^{[1
]}

机构：

[1] Peoples Hosp Zhengzhou, Dept Resp Med, Zhengzhou 450003, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 10期

关键词：

Asthma; apigenin; airway smooth muscle cells; transforming growth factor-beta 1; TGF-BETA; ASTHMA; EXPRESSION; APOPTOSIS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

It is well known that the proliferation and migration of ASM cells (ASMCs) plays an important role in the pathogenesis of airway remodeling in asthma. Previous studies reported that apigenin can inhibit airway remodeling in a mouse asthma model. However, its effects on the proliferation and migration of ASMCs in asthma remain unknown. Therefore, the aim of our present study was to investigate the effects of apigenin on ASMC proliferation and migration, and explore the possible molecular mechanism. We found that apigenin inhibited transforming growth factor-beta 1 (TGF-beta 1)-induced ASMC proliferation. The cell cycle was blocked at G1/S-interphase by apigenin. It also suppressed TGF-beta 1-induced ASMCs migration. Furthermore, apigenin inhibited TGF-beta 1-induced Smad 2 and Smad 3 phosphorylation in ASMCs. Taken together, these results suggested that apigenin inhibited the proliferation and migration of TGF-beta 1-stimulated ASMCs by inhibiting Smad signaling pathway. These data might provide useful information for treating asthma and show that apigenin has potential for attenuating airway remodeling.

引用

页码：12557 / 12563

页数：7

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