Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene

被引：43

作者：

Choi, Jun-Rim ^{[2
,3
]}

Lee, Chang-Min ^{[2
,3
]}

Jung, In Duk ^{[2
,3
]}

Lee, Jun Sik ^{[2
,3
]}

Jeong, Young-Il ^{[4
]}

Chang, Jeong Hyun ^{[5
]}

Park, Hee-ju ^{[6
]}

Choi, Il-Whan ^{[7
]}

Kim, Jong-Suk ^{[8
]}

Shin, Yong Kyoo ^{[9
]}

Park, Sung Nam ^{[2
,3
]}

Park, Yeong-Min ^{[1
,2
,3
]}

机构：

[1] Pusan Natl Univ, Coll Med, Dept Microbiol & Immunol, Sch Med, Pusan 602739, South Korea

[2] Pusan Natl Univ, Natl Res Lab Dendrit Cell Differentiat & Regulat, Sch Med, Pusan 602739, South Korea

[3] Pusan Natl Univ, Med Res Inst, Sch Med, Pusan 602739, South Korea

[4] Pusan Natl Univ, Coll Nat Sci, Dept Microbiol, Pusan 609735, South Korea

[5] Daegu Haany Univ, Coll Hlth & Therapy, Dept Clin Lab Sci, Gyeong San 712715, South Korea

[6] Pusan Natl Univ, Sch Med, Dept Pediat, Pusan 602739, South Korea

[7] Inje Univ, Coll Med, Dept Microbiol, Pusan 614735, South Korea

[8] Chonbuk Natl Univ, Sch Med, Dept Biochem, Jeonju 561180, South Korea

[9] Chung Ang Univ, Coll Med, Dept Pharmacol, Seoul 156756, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2009年 / 9卷 / 7-8期

关键词：

Apigenin; Asthma; GATA-3; MMP-9; AHR; T-CELLS; BASEMENT-MEMBRANE; IN-VITRO; MATRIX METALLOPROTEINASES; TRANSCRIPTION FACTOR; AIRWAY INFLAMMATION; LINEAGE COMMITMENT; DENDRITIC CELLS; KAPPA-B; BET;

D O I：

10.1016/j.intimp.2009.03.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apigenin, a dietary plant-flavonoid has shown anti-inflammatory and anticancer properties however the, molecular basis of this effect remains to be elucidated. Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions. It included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of apigenin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that apigenin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of apigenin in terms of its effects in a murine model of asthma. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：918 / 924

页数：7

共 41 条

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