Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics

被引：37

作者：

Gunnlaugsson, T ^{[1
]}

Davies, RJH

Nieuwenhuyzen, M

Stevenson, CS

Viguier, R

Mulready, S

机构：

[1] Univ Dublin Trinity Coll, Dept Chem, Dublin 2, Ireland

[2] Queens Univ Belfast, Sch Biol & Biochem, Belfast BT9 7BL, Antrim, North Ireland

[3] Queens Univ Belfast, Sch Chem, Belfast BT9 5AG, Antrim, North Ireland

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 18期

关键词：

D O I：

10.1039/b205349g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The lanthanide ion based macrocyclic complexes 1.Ln mimic the hydrophobic nature of ribonucleases, where the lanthanide ions induce the formation of a hydrophobic cavity for 1, giving rise to a large order of magnitude enhancement in the hydrolytic cleavage of HPNP.

引用

页码：2136 / 2137

页数：2

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