Reconstructing aldolase antibodies to alter their substrate specificity and turnover

被引：48

作者：

Tanaka, F

Lerner, RA

Barbas, CF

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 19期

关键词：

D O I：

10.1021/ja0005441

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：4835 / 4836

页数：2

共 34 条

[11] CORRELATION BETWEEN ANTIGEN-COMBINING-SITE STRUCTURES AND FUNCTIONS WITHIN A PANEL OF CATALYTIC ANTIBODIES GENERATED AGAINST A SINGLE TRANSITION-STATE ANALOG [J].

FUJII, I ;

TANAKA, F ;

MIYASHITA, H ;

TANIMURA, R ;

KINOSHITA, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (23) :6199-6209

[12] Evolving catalytic antibodies in a phage-displayed combinatorial library [J].

Fujii, I ;

Fukuyama, S ;

Iwabuchi, Y ;

Tanimura, R .

NATURE BIOTECHNOLOGY, 1998, 16 (05) :463-467

[13] Aldolase antibodies of remarkable scope [J].

Hoffmann, T ;

Zhong, GF ;

List, B ;

Shabat, D ;

Anderson, J ;

Gramatikova, S ;

Lerner, RA ;

Barbas, CF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (12) :2768-2779

[14] V-GENES OF OXAZOLONE ANTIBODIES IN 10 STRAINS OF MICE [J].

KAARTINEN, M ;

SOLIN, ML ;

MAKELA, O .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (11) :2863-2869

[15]

Kabat E. A., 1991, SEQUENCES PROTEINS I

[16] Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis [J].

List, B ;

Barbas, CF ;

Lerner, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15351-15355

[17] A catalytic enantioselective route to hydroxy-substituted quaternary carbon centers: Resolution of tertiary aldols with a catalytic antibody [J].

List, B ;

Shabat, D ;

Zhong, GF ;

Turner, JM ;

Li, A ;

Bui, T ;

Anderson, J ;

Lerner, RA ;

Barbas, CF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (32) :7283-7291

[18] Enantioselective aldol cyclodehydrations catalyzed by antibody 38C2 [J].

List, B ;

Lerner, RA ;

Barbas, CF .

ORGANIC LETTERS, 1999, 1 (01) :59-61

[19]

List B, 1998, CHEM-EUR J, V4, P881, DOI 10.1002/(SICI)1521-3765(19980515)4:5<881::AID-CHEM881>3.0.CO

[20]

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