Metabolic profiles of cancer cells

被引：568

作者：

Griffin, JL

Shockcor, JP

机构：

[1] Bruker Biospin, Billerica, MA 01821 USA

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrc1390

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the post-genomic era, several profiling tools have been developed to provide a more comprehensive picture of tumour development and progression. The global analysis of metabolites, such as by mass spectrometry and high-resolution H-1 nuclear magnetic resonance spectroscopy, can be used to define the metabolic phenotype of cells, tissues or organisms. These 'metabolomic' approaches are providing important information about tumorigenesis, revealing new therapeutic targets and will be an important component of automated diagnosis.

引用

收藏

页码：551 / 561

页数：11

相关论文

共 96 条

[11]

Celis JE, 1999, CANCER RES, V59, P3003

[12] Biochemical analysis using high-resolution magic angle spinning NMR spectroscopy distinguishes lipoma-like well-differentiated liposarcoma from normal fat [J].

Chen, JH ;

Enloe, BM ;

Fletcher, CD ;

Cory, DG ;

Singer, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (37) :9200-9201

[13] Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic-angle spinning [J].

Cheng, LL ;

Lean, CL ;

Bogdanova, A ;

Wright, SC ;

Ackerman, JL ;

Brady, TJ ;

Garrido, L .

MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) :653-658

[14] Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy [J].

Cheng, LL ;

Chang, IW ;

Smith, BL ;

Gonzalez, RG .

JOURNAL OF MAGNETIC RESONANCE, 1998, 135 (01) :194-202

[15] The transcriptional program of sporulation in budding yeast [J].

Chu, S ;

DeRisi, J ;

Eisen, M ;

Mulholland, J ;

Botstein, D ;

Brown, PO ;

Herskowitz, I .

SCIENCE, 1998, 282 (5389) :699-705

[16]

Chung YL, 2003, METABOLIC PROFILING: ITS ROLE IN BIOMARKER DISCOVERY AND GENE FUNCTION ANALYSIS, P83

[17] Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models [J].

Chung, YL ;

Troy, H ;

Banerji, U ;

Jackson, LE ;

Walton, MI ;

Stubbs, M ;

Griffiths, JR ;

Judson, IR ;

Leach, MO ;

Workman, P ;

Ronen, SM .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (21) :1624-1633

[18]

Chung Yuen-Li, 2002, Proceedings of the American Association for Cancer Research Annual Meeting, V43, P73

[19]

Chung Yuen-Li, 2002, Proceedings of the American Association for Cancer Research Annual Meeting, V43, P336

[20] The cell and developmental biology of alkaloid biosynthesis [J].

De Luca, V ;

St Pierre, B .

TRENDS IN PLANT SCIENCE, 2000, 5 (04) :168-173

← 1 2 3 4 5 6 7 8 9 10 →