Performance of classification criteria for gout in early and established disease

被引：30

作者：

Taylor, William J. ^{[1
]}

Fransen, Jaap ^{[2
]}

Dalbeth, Nicola ^{[3
]}

Neogi, Tuhina ^{[4
]}

Schumacher, H. Ralph ^{[5
]}

Brown, Melanie ^{[1
]}

Louthrenoo, Worawit ^{[6
]}

Vazquez-Mellado, Janitzia ^{[7
]}

Eliseev, Maxim ^{[8
]}

McCarthy, Geraldine ^{[9
,10
]}

Stamp, Lisa K. ^{[11
]}

Perez-Ruiz, Fernando ^{[12
,13
]}

Sivera, Francisca ^{[14
]}

Ea, Hang-Korng ^{[15
,16
,17
]}

Gerritsen, Martijn ^{[18
]}

Scire, Carlo ^{[19
]}

Cavagna, Lorenzo ^{[20
,21
]}

Lin, Chingtsai ^{[22
]}

Chou, Yin-Yi ^{[23
]}

Tausche, Anne-Kathrin ^{[24
]}

Castelar-Pinheiro, Geraldo da Rocha ^{[25
]}

Janssen, Matthijs ^{[26
]}

Chen, Jiunn-Horng ^{[27
,28
]}

Slot, Ole ^{[29
]}

Cimmino, Marco ^{[30
,31
]}

Uhlig, Till ^{[32
]}

Jansen, Tim L. ^{[2
]}

机构：

[1] Univ Otago, Dept Med, Wellington 6039, New Zealand

[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6525 ED Nijmegen, Netherlands

[3] Univ Auckland, Dept Med, Auckland, New Zealand

[4] Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USA

[5] Univ Penn, Vet Adm Med Ctr, Philadelphia, PA 19104 USA

[6] Chiang Mai Univ, Fac Med, Dept Internal Med, Div Rheumatol, Chiang Mai 50000, Thailand

[7] Hosp Gen Mexico City, Serv Reumatol, Mexico City, DF, Mexico

[8] Nasonova Res Inst Rheumatol Russia, Moscow, Russia

[9] Univ Coll Dublin, Sch Med & Med Sci, Dublin 2, Ireland

[10] Mater Misericordiae Univ Hosp, Dept Rheumatol, Dublin, Ireland

[11] Univ Otago, Dept Med, Canterbury, New Zealand

[12] Hosp Univ Cruces, Div Rheumatol, Vizcaya, Spain

[13] BioCruces Hlth Res Inst, Vizcaya, Spain

[14] Hosp Gen Univ Elda, Dept Reumatol, Alicante, Spain

[15] Univ Paris Diderot, Sorbonne Paris Cite, UFR Med, Paris, France

[16] Hop Lariboisiere, INSERM, UMR 1132, F-75475 Paris, France

[17] Hop Lariboisiere, AP HP, Serv Rhumatol, Ctr Viggo Petersen, F-75475 Paris, France

[18] Westfries Gasthuis, Amsterdam Rheumatol Immunol Ctr ARC, Dept Rheumatol, Hoorn, Netherlands

[19] Italian Soc Rheumatol SIR, Epidemiol Unit, Milan, Italy

[20] Univ Pavia, Div Rheumatol, I-27100 Pavia, Italy

[21] IRCCS Policlin S Matteo Fdn, Pavia, Italy

[22] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Div Rheumatol & Immunol, Taichung, Taiwan

[23] Taichung Vet Gen Hosp, Taichung, Taiwan

[24] Univ Hosp Carl Gustav Carus, Dept Internal Med 3, Div Rheumatol, Dresden, Germany

[25] Univ Estado Rio de Janeiro, Dept Internal Med, Div Rheumatol, Rio De Janeiro, Brazil

[26] Rijnstate Hosp, Dept Rheumatol, Arnhem, Netherlands

[27] China Med Univ, Sch Med, Taichung, Taiwan

[28] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan

[29] Copenhagen Univ Hosp Glostrup, Ctr Rheumatol & Spine Disorders, Glostrup, Denmark

[30] Univ Genoa, Dept Internal Med, Res Lab, I-16126 Genoa, Italy

[31] Univ Genoa, Dept Internal Med, Acad Div Clin Rheumatol, I-16126 Genoa, Italy

[32] Diakonhjemmet Hosp, Dept Rheumatol, Natl Advisory Unit Rehabil Rheumatol, Oslo, Norway

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2016年 / 75卷 / 01期

关键词：

DIAGNOSIS; RECOMMENDATIONS; ARTHRITIS; PROPOSAL;

D O I：

10.1136/annrheumdis-2014-206364

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objectives To compare the sensitivity and specificity of different classification criteria for gout in early and established disease. Methods This was a cross-sectional study of consecutive rheumatology clinic patients with joint swelling in which gout was defined by presence or absence of monosodium urate crystals as observed by a certified examiner at presentation. Early disease was defined as patient-reported onset of symptoms of 2 years or less. Results Data from 983 patients were collected and gout was present in 509 (52%). Early disease was present in 144 gout cases and 228 non-cases. Sensitivity across criteria was better in established disease (95.3% vs 84.1%, p<0.001) and specificity was better in early disease (79.9% vs 52.5%, p<0.001). The overall best performing clinical criteria were the Rome criteria with sensitivity/specificity in early and established disease of 60.3%/84.4% and 86.4%/63.6%. Criteria not requiring synovial fluid analysis had sensitivity and specificity of less than 80% in early and established disease. Conclusions Existing classification criteria for gout have sensitivity of over 80% in early and established disease but currently available criteria that do not require synovial fluid analysis have inadequate specificity especially later in the disease. Classification criteria for gout with better specificity are required, although the findings should be cautiously applied to non-rheumatology clinic populations.

引用

页码：178 / 182

页数：5

共 16 条

[1]

Berendsen D, 2013, ANN RHEUM DIS, V72, P981

[2]

Hyperuricaemia and gout: time for a new staging system? [J].