Function of SIRT1 in physiology

被引：42

作者：

Kong, Xing-Xing

Wang, Rui

Liu, Xiao-Jun

Zhu, Liu-Luan

Shao, Di

Chang, Yong-Sheng ^{[1
]}

Fang, Fu-De

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China

来源：

BIOCHEMISTRY-MOSCOW | 2009年 / 74卷 / 07期

关键词：

SIRT1; metabolism; calorie restriction; apoptosis; ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELLS; ACETYL-COA SYNTHETASE; CALORIE RESTRICTION; GLUCOSE-HOMEOSTASIS; HISTONE DEACETYLASE; INSULIN-SECRETION; LIPID-METABOLISM; INCREASED DOSAGE; PPAR-GAMMA;

D O I：

10.1134/S0006297909070013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins were originally defined as a family of oxidized nicotinamide adenine nucleotide (NAD(+))-dependent enzymes that deacetylate lysine residues on various proteins. The sirtuins are remarkably conserved throughout evolution from archae to eukaryotes. They were named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). The mammalian sirtuins, SIRT1-7, are implicated in a variety of cellular functions ranging from gene silencing, control of the cell cycle and apoptosis, and energy homeostasis. As SIRT1 is a nuclear protein and is the mammalian homolog most highly related to Sir2, it has been the focus of a large number of recent studies. Here we review some of the current data related to SIRT1 and discuss its mode of action and biological role in cellular and organismal models.

引用

页码：703 / 708

页数：6

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