Human Adult Neurogenesis: Evidence and Remaining Questions

被引：605

作者：

Kempermann, Gerd ^{[1
,2
]}

Gage, Fred H. ^{[3
]}

Aigner, Ludwig ^{[4
]}

Song, Hongjun ^{[5
]}

Curtis, Maurice A. ^{[6
,7
]}

Thuret, Sandrine ^{[8
]}

Kuhn, H. Georg ^{[9
,10
]}

Jessberger, Sebastian ^{[11
]}

Frankland, Paul W. ^{[12
]}

Cameron, Heather A. ^{[13
]}

Gould, Elizabeth ^{[14
]}

Hen, Rene ^{[15
,16
]}

Abrous, D. Nora ^{[17
]}

Toni, Nicolas ^{[18
]}

Schinder, Alejandro F. ^{[19
]}

Zhao, Xinyu ^{[20
,21
]}

Lucassen, Paul J. ^{[22
]}

Frisen, Jonas ^{[23
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE Dresden, Dresden, Germany

[2] Tech Univ Dresden, CRTD, Dresden, Germany

[3] Salk Inst Biol Studies, Genet Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

[4] Paracelsus Med Univ, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, Inst Mol Regenerat Med, Salzburg, Austria

[5] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA

[6] Univ Auckland, Dept Anat & Med Imaging, Auckland, New Zealand

[7] Univ Auckland, Ctr Brain Res, Auckland, New Zealand

[8] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England

[9] Univ Gothenburg, Inst Neurosci & Physiol, Sect Clin Neurosci, Gothenburg, Sweden

[10] Charite Univ Med Berlin, Neurocure Cluster Excellence, Berlin, Germany

[11] Univ Zurich, HiFo Brain Res Inst, Zurich, Switzerland

[12] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5GOA4, Canada

[13] NIMH, Sect Neuroplast, NIH, Bethesda, MD 20892 USA

[14] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA

[15] Columbia Univ, Dept Neurosci, New York, NY USA

[16] Columbia Univ, Dept Psychiat, New York, NY USA

[17] INSERM, Neuroctr Magendie, Bordeaux, France

[18] Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Neurosci, Lausanne, Switzerland

[19] Consejo Nacl Invest Cient & Tecn, Leloir Inst, Neuronal Plast Lab, Buenos Aires, DF, Argentina

[20] Univ Wisconsin Madison, Sch Med & Publ Hlth, Waisman Ctr, Madison, WI USA

[21] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Neurosci, Madison, WI USA

[22] Univ Amsterdam, Ctr Neurosci, Swammerdam Inst Life Sci, Brain Plast Grp, Amsterdam, Netherlands

[23] Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden

来源：

CELL STEM CELL | 2018年 / 23卷 / 01期

关键词：

ENHANCED SYNAPTIC PLASTICITY; HIPPOCAMPAL NEUROGENESIS; HUMAN BRAIN; DENTATE GYRUS; GRANULE CELLS; NEURONS; PROLIFERATION; DOUBLECORTIN; PERIOD; RATS;

D O I：

10.1016/j.stem.2018.04.004

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

引用

页码：25 / 30

页数：6

共 34 条

[1]

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas [J].

Abrous, Djoher Nora ;

Wojtowicz, Jan Martin .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2015, 7 (06) :1-24

[2]

AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].

ALTMAN, J ;

DAS, GD .

JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&

[3]

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis [J].

Amrein, Irmgard ;

Slomianka, Lutz .

BRAIN RESEARCH, 2010, 1328 :12-24

[4]

Bao AM, 2018, HAND CLINIC, V150, P197, DOI 10.1016/B978-0-444-63639-3.00015-3

[5]

The cell cycle-apoptosis connection revisited in the adult brain [J].

Bauer, S ;

Patterson, PH .

JOURNAL OF CELL BIOLOGY, 2005, 171 (04) :641-650

[6]

Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus [J].

Boekhoorn, Karin ;

Joels, Marian ;

Lucassen, Paul J. .

NEUROBIOLOGY OF DISEASE, 2006, 24 (01) :1-14

[7]

Human Hippocampal Neurogenesis Persists throughout Aging [J].

Boldrini, Maura ;

Fulmore, Camille A. ;

Tartt, Alexandria N. ;

Simeon, Laika R. ;

Pavlova, Ina ;

Poposka, Verica ;

Rosoklija, Gorazd B. ;

Stankov, Aleksandar ;

Arango, Victoria ;

Dwork, Andrew J. ;

Hen, Rene ;

Mann, J. John .

CELL STEM CELL, 2018, 22 (04) :589-+

[8]

MICROBATS APPEAR TO HAVE ADULT HIPPOCAMPAL NEUROGENESIS, BUT POST-CAPTURE STRESS CAUSES A RAPID DECLINE IN THE NUMBER OF NEURONS EXPRESSING DOUBLECORTIN [J].

Chawana, R. ;

Alagaili, A. ;

Patzke, N. ;

Spocter, M. A. ;

Mohammed, O. B. ;

Kaswera, C. ;

Gilissen, E. ;

Bennett, N. C. ;

Ihunwo, A. O. ;

Manger, P. R. .

NEUROSCIENCE, 2014, 277 :724-733

[9]

Functions and Dysfunctions of Adult Hippocampal Neurogenesis [J].

Christian, Kimberly M. ;

Song, Hongjun ;

Ming, Guo-li .

ANNUAL REVIEW OF NEUROSCIENCE, VOL 37, 2014, 37 :243-262

[10]

Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans [J].

Coras, Roland ;

Siebzehnrubl, Florian A. ;

Pauli, Elisabeth ;

Huttner, Hagen B. ;

Njunting, Marleisje ;

Kobow, Katja ;

Villmann, Carmen ;

Hahnen, Eric ;

Neuhuber, Winfried ;

Weigel, Daniel ;

Buchfelder, Michael ;

Stefan, Hermann ;

Beck, Heinz ;

Steindler, Dennis A. ;

Bluemcke, Ingmar .

BRAIN, 2010, 133 :3359-3372

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