Human Hippocampal Neurogenesis Persists throughout Aging

被引：1071

作者：

Boldrini, Maura ^{[1
,5
]}

Fulmore, Camille A. ^{[5
]}

Tartt, Alexandria N. ^{[5
]}

Simeon, Laika R. ^{[5
]}

Pavlova, Ina ^{[6
]}

Poposka, Verica ^{[8
]}

Rosoklija, Gorazd B. ^{[1
,5
,7
]}

Stankov, Aleksandar ^{[8
]}

Arango, Victoria ^{[1
,5
]}

Dwork, Andrew J. ^{[1
,2
,5
,7
]}

Hen, Rene ^{[1
,3
,4
,6
]}

Mann, J. John ^{[1
,5
]}

机构：

[1] Columbia Univ, Dept Psychiat, New York, NY 10032 USA

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

[3] Columbia Univ, Dept Neurosci, New York, NY 10032 USA

[4] Columbia Univ, Dept Pharmacol, New York, NY 10032 USA

[5] NYS Psychiat Inst, Div Mol Imaging & Neuropathol, New York, NY 10032 USA

[6] NYS Psychiat Inst, Div Integrat Neurosci, New York, NY 10032 USA

[7] Ss Cyril & Methodius Univ, Macedonian Acad Sci & Arts, Skopje 1000, Macedonia

[8] Ss Cyril & Methodius Univ, Inst Forens Med, Skopje 1000, Macedonia

来源：

CELL STEM CELL | 2018年 / 22卷 / 04期

关键词：

NEURAL PROGENITOR CELLS; ADULT DENTATE GYRUS; ALZHEIMERS-DISEASE; HUMAN BRAIN; STEM-CELLS; PATTERN SEPARATION; MAJOR DEPRESSION; CHRONIC STRESS; OLD-AGE; NEURONS;

D O I：

10.1016/j.stem.2018.03.015

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Adult hippocampal neurogenesis declines in aging rodents and primates. Aging humans are thought to exhibit waning neurogenesis and exercise-induced angiogenesis, with a resulting volumetric decrease in the neurogenic hippocampal dentate gyrus (DG) region, although concurrent changes in these parameters are not well studied. Here we assessed whole autopsy hippocampi from healthy human individuals ranging from 14 to 79 years of age. We found similar numbers of intermediate neural progenitors and thousands of immature neurons in the DG, comparable numbers of glia and mature granule neurons, and equivalent DG volume across ages. Nevertheless, older individuals have less angiogenesis and neuro-plasticity and a smaller quiescent progenitor pool in anterior-mid DG, with no changes in posterior DG. Thus, healthy older subjects without cognitive impairment, neuropsychiatric disease, or treatment display preserved neurogenesis. It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive function throughout life and that declines may be linked to compromised cognitive-emotional resilience.

引用

页码：589 / +

页数：16

共 69 条

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