High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori

被引:30
作者
Cao, P
Cover, TL
机构
[1] VANDERBILT UNIV,MED CTR,SCH MED,DIV INFECT DIS,DEPT MED,NASHVILLE,TN 37232
[2] DEPT VET AFFAIRS MED CTR,NASHVILLE,TN 37232
关键词
D O I
10.1128/jb.179.9.2852-2856.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Helicobacter pylori isolates from different patients are characterized By diversity in the nucleotide sequences of individual genes, variation in genome size, and variation in gene order, Genetic diversity is particularly striking in vacuolating cytotoxin (vacA) alleles, In this study, five open reading frames (ORFs) were identified within a 4,2-kb region downstream from vacA in H. pylori 60190, One of these ORFs was closely related to the virulence-associated protein D (vapD) gene of Dichelobacter nodosus (64.9% nucleotide identity), A probe derived from vapD of H. pylori 60190 hybridized with only 19 (61.3%) of 31 H. pylori strains tested, Sequence analysis of the vapD region in vapD-negative H. pylori strains revealed that there were two different families of similar to 0.5-kb DNA segments, which were both unrelated to vapD. The presence of vapD was not associated with any specific family of vacA alleles, These findings are consistent with a recombinational population structure for H. pylori.
引用
收藏
页码:2852 / 2856
页数:5
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