Microbubble tunneling in gel phantoms

被引：49

作者：

Caskey, Charles F. ^{[1
]}

Qin, Shengping ^{[1
]}

Dayton, Paul A. ^{[2
]}

Ferrara, Katherine W. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[2] N Carolina State Univ, Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27514 USA

来源：

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA | 2009年 / 125卷 / 05期

关键词：

ULTRASOUND CONTRAST AGENTS; BLOOD-BRAIN-BARRIER; DIAGNOSTIC ULTRASOUND; BUBBLE DYNAMICS; CAVITATION; DISRUPTION; TISSUE; DESTRUCTION; DELIVERY; BEHAVIOR;

D O I：

10.1121/1.3097679

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Insonified microbubbles were observed in vessels within a gel with a Young's modulus similar to that of tissue, demonstrating shape instabilities, liquid jets, and the formation of small tunnels. In this study, tunnel formulation occurred in the direction of the propagating ultrasound wave, where radiation pressure directed the contact of the bubble and gel, facilitating the activity of the liquid jets. Combinations of ultrasonic parameters and microbubble concentrations that are relevant for diagnostic imaging and drug delivery and that lead to tunnel formation were applied and the resulting tunnel formation was quantified. (C) 2009 Acoustical Society of America

引用

页码：EL183 / EL189

页数：7

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