Modest implication of interleukin-6 promoter polymorphisms in longevity

被引:44
作者
Christiansen, L [1 ]
Bathum, L
Andersen-Ranberg, K
Jeune, B
Christensen, K
机构
[1] Univ So Denmark, Inst Publ Hlth, Dept Epidemiol, Odense, Denmark
[2] Odense Univ Hosp, Dept Clin Biochem & Clin Genet, DK-5000 Odense, Denmark
关键词
interleukin-6; polymorphisms; haplotype; ageing; longevity;
D O I
10.1016/j.mad.2004.03.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The multifunctional interleukin-6 has been suggested to contribute to a chronic low-grade inflammatory status, thereby conferring susceptibility to age-related pathological conditions as well as functional decline and increased mortality. Several polymorphisms have been identified in the interleukin-6 promoter, but investigation of the effect of these on interleukin-6 levels and disease susceptibility have led to contradictory results. This study investigates the significance of the three single-point polymorphisms (-597G/A, -572G/C and -174G/C) and the AT-stretch polymorphism (-373(A)n(T)m) in ageing, by comparison of the frequency of each single polymorphism separately as well as the entire promoter haplotype in a total of 1710 Danish subjects ranging in age from 47 to 100 years. We found a modest, but significant, increase in the frequency of interleukin-6-174GG homozygotes with age suggesting that this genotype is advantageous for longevity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:391 / 395
页数:5
相关论文
共 29 条
[1]   Healthy centenarians do not exist, but autonomous centenarians do: A population-based study of morbidity among Danish centenarians [J].
Andersen-Ranberg, K ;
Schroll, M ;
Jeune, B .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2001, 49 (07) :900-908
[2]   Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons [J].
Barbieri, M ;
Ferrucci, L ;
Ragno, E ;
Corsi, A ;
Bandinelli, S ;
Bonafè, M ;
Olivieri, F ;
Giovagnetti, S ;
Franceschi, C ;
Guralnik, JM ;
Paolisso, G .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 284 (03) :E481-E487
[3]   Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer's disease (DAT): Lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT [J].
Bonaccorso, S ;
Lin, A ;
Song, C ;
Verkerk, R ;
Kenis, G ;
Bosmans, E ;
Scharpe, S ;
Vandewoude, M ;
Dossche, A ;
Maes, M .
AGING-CLINICAL AND EXPERIMENTAL RESEARCH, 1998, 10 (04) :316-323
[4]   Interleukin-6 gene -174G > C and -572G > C promoter polymorphisms are strong predictors of plasma -: Interleukin-6 levels after coronary artery bypass surgery [J].
Brull, DJ ;
Montgomery, HE ;
Sanders, J ;
Dhamrait, S ;
Luong, L ;
Rumley, A ;
Lowe, GDO ;
Humphries, SE .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (09) :1458-1463
[5]   A high plasma concentration of TNF-α is associated with dementia in centenarians [J].
Bruunsgaard, H ;
Andersen-Ranberg, K ;
Jeune, B ;
Pedersen, AN ;
Skinhoj, P ;
Pedersen, BK .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1999, 54 (07) :M357-M364
[6]   Aging and proinflammatory cytokines [J].
Bruunsgaard, H ;
Pedersen, M ;
Pedersen, BK .
CURRENT OPINION IN HEMATOLOGY, 2001, 8 (03) :131-136
[7]  
CHAKRAVARTI A, 1984, AM J HUM GENET, V36, P1239
[8]   Genetic contribution to rate of change in functional abilities among Danish twins aged 75 years or more [J].
Christensen, K ;
Gaist, D ;
Vaupel, JW ;
McGue, M .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (02) :132-139
[9]   MORTALITY AMONG TWINS AFTER AGE-6 - FETAL ORIGINS HYPOTHESIS VERSUS TWIN METHOD [J].
CHRISTENSEN, K ;
VAUPEL, JW ;
HOLM, NV ;
YASHIN, AI .
BRITISH MEDICAL JOURNAL, 1995, 310 (6977) :432-436
[10]   The association of plasma IL-6 levels with functional disability in community-dwelling elderly [J].
Cohen, HJ ;
Pieper, CF ;
Harris, T ;
Rao, KMK ;
Currie, MS .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1997, 52 (04) :M201-M208