Modest implication of interleukin-6 promoter polymorphisms in longevity

被引：44

作者：

Christiansen, L ^{[1
]}

Bathum, L

Andersen-Ranberg, K

Jeune, B

Christensen, K

机构：

[1] Univ So Denmark, Inst Publ Hlth, Dept Epidemiol, Odense, Denmark

[2] Odense Univ Hosp, Dept Clin Biochem & Clin Genet, DK-5000 Odense, Denmark

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 05期

关键词：

interleukin-6; polymorphisms; haplotype; ageing; longevity;

D O I：

10.1016/j.mad.2004.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The multifunctional interleukin-6 has been suggested to contribute to a chronic low-grade inflammatory status, thereby conferring susceptibility to age-related pathological conditions as well as functional decline and increased mortality. Several polymorphisms have been identified in the interleukin-6 promoter, but investigation of the effect of these on interleukin-6 levels and disease susceptibility have led to contradictory results. This study investigates the significance of the three single-point polymorphisms (-597G/A, -572G/C and -174G/C) and the AT-stretch polymorphism (-373(A)n(T)m) in ageing, by comparison of the frequency of each single polymorphism separately as well as the entire promoter haplotype in a total of 1710 Danish subjects ranging in age from 47 to 100 years. We found a modest, but significant, increase in the frequency of interleukin-6-174GG homozygotes with age suggesting that this genotype is advantageous for longevity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：391 / 395

页数：5

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