MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

被引：670

作者：

Oliphant, Christopher J. ^{[1
]}

Hwang, You Yi ^{[1
]}

Walker, Jennifer A. ^{[1
]}

Salimi, Maryam ^{[2
]}

Wong, See Heng ^{[1
]}

Brewer, James M. ^{[6
]}

Englezakis, Alexandros ^{[1
]}

Barlow, Jillian L. ^{[1
]}

Hams, Emily ^{[3
]}

Scanlon, Seth T. ^{[1
]}

Ogg, Graham S. ^{[2
]}

Fallon, Padraic G. ^{[3
,4
,5
]}

McKenzie, Andrew N. J. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

[2] Univ Oxford, John Radcliffe Hosp, NIHR Biomed Res Ctr, MRC Human Immunol Unit, Oxford OX3 9DS, England

[3] Trinity Coll Dublin, Trinity Biomed Sci Inst, Dublin 2, Ireland

[4] Our Ladys Childrens Hosp, Natl Childrens Res Ctr, Dublin 12, Ireland

[5] Trinity Coll Dublin, Inst Mol Med, Dublin 2, Ireland

[6] Univ Pl, GRBC, Inst Infect Immun & Inflammat, Glasgow G12 8TA, Lanark, Scotland

来源：

IMMUNITY | 2014年 / 41卷 / 02期

基金：

爱尔兰科学基金会; 英国惠康基金; 英国医学研究理事会;

关键词：

CYSTEINE PROTEASE; TH2; IMMUNITY; IN-VIVO; IL-4; EXPRESSION; RESPONSES; INFLAMMATION; CONTRIBUTE; INDUCTION; CYTOKINES;

D O I：

10.1016/j.immuni.2014.06.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCII-expressing ILC2s interact with antigen-specific T cells to instigate a dialog in which IL-2 production from T cells promotes ILC2 proliferation and IL-13 production. Deletion of MHCII renders IL-13-expressing ILC2s incapable of efficiently inducing Nippostrongylus brasiliensis expulsion. Thus, during transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production. This interaction appears to augment dendritic-cell-induced T cell activation and identifies a previously unappreciated pathway in the regulation of type-2 immunity.

引用

页码：283 / 295

页数：13

共 44 条

[1]

Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity [J].