Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes

被引：66

作者：

Bernardi, Stella ^{[1
,2
,3
]}

Fabris, Bruno ^{[4
]}

Thomas, Merlin ^{[3
]}

Toffoli, Barbara ^{[5
]}

Tikellis, Christos ^{[3
]}

Candido, Riccardo ^{[6
]}

Catena, Cristiana ^{[8
]}

Mulatero, Paolo ^{[9
]}

Barbone, Fabio ^{[7
]}

Radillo, Oriano ^{[5
]}

Zauli, Giorgio ^{[5
]}

Secchiero, Paola ^{[1
,2
]}

机构：

[1] Univ Ferrara, Dept Morphol Surg & Expt Med, I-44100 Ferrara, Italy

[2] Univ Ferrara, LTTA Ctr, I-44100 Ferrara, Italy

[3] Heart & Diabet Res Inst, Baker IDI, Melbourne, Vic 3004, Australia

[4] Univ Trieste, Osped Cattinara, Dept Med Surg & Hlth Sci, I-34149 Trieste, Italy

[5] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34100 Trieste, Italy

[6] Diabetol Ctr, I-34148 Trieste, Italy

[7] Univ Udine, Osped Santa Maria della Misericordia, Dept Med Expt & Clin Sci, I-33100 Udine, Italy

[8] Univ Udine, Osped Santa Maria della Misericordia, Dept Med & Biol Sci, I-33100 Udine, Italy

[9] Univ Turin, Osped San Giovanni Battista, Div Internal Med & Hypertens, I-10126 Turin, Italy

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 394卷 / 1-2期

关键词：

Metabolic syndrome; High-fat diet; Adipose tissue; Osteoprotegerin; Inflammation; FULL-LENGTH OSTEOPROTEGERIN; NECROSIS-FACTOR-ALPHA; SMOOTH-MUSCLE-CELLS; KAPPA-B LIGAND; INSULIN-RESISTANCE; RECEPTOR ACTIVATOR; DIABETES-MELLITUS; CIRCULATING OSTEOPROTEGERIN; OBESE WOMEN; WEIGHT-LOSS;

D O I：

10.1016/j.mce.2014.06.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Background: Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that seems to exert proatherogenic and prodiabetogenic effects. This study aims at determining OPG levels in MetS and whether OPG might contribute to MetS development and progression. Methodology/principal findings: Circulating OPG was measured in 46 patients with MetS and 63 controls, and was found significantly elevated in those with MetS. In addition, circulating and tissue OPG was significantly increased in high-fat diet (HFD) fed C57BL6 mice, which is one of the animal models for the study of MetS. To evaluate the consequences of OPG elevation, we delivered this protein to C57BL6 mice, finding that it promoted systemic and adipose tissue proinflammatory changes in association with metabolic abnormalities. Conclusions/significance: These data suggest that OPG may trigger adipose tissue proinflammatory changes in MetS/HFD-induced obesity. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：13 / 20

页数：8

共 55 条

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Increased osteoprotegerin levels in women with previous gestational diabetes developing metabolic syndrome [J].