Prevalence, incidence, and mother-to-child transmission of HIV-1 in rural South Africa

被引：43

作者：

Rollins, NC

Dedicoat, M

Danaviah, S

Page, T

Bishop, K

Kleinschmidt, I

Coovadia, HM

Cassol, SA ^{[1
]}

机构：

[1] Africa Ctr Hlth & Populat Studies, Kwa Zulu, South Africa

[2] Univ Natal, Dept Paediat & Child Hlth, ZA-4001 Durban, South Africa

[3] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

[4] S African Med Council, Durban, South Africa

[5] Univ Natal, Ctr HIV AIDS Networking, ZA-4001 Durban, South Africa

来源：

LANCET | 2002年 / 360卷 / 9330期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(02)09599-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Simple, robust approaches are needed to monitor prevalence, incidence, and mother-to-child transmission of HIV-1 in rural Africa. We have designed a method that uses antibody and viral RNA testing of dried blood spots obtained from mother-infant pairs attending routine immunisation clinics. In our study, prevalence and incidence of HIV-1 was highest in young women in their late teens and early twenties. In children born to infected mothers, prevalence increased from 14% in infants younger than 6 weeks of age to 24% at 3-6 months. The blood-spot approach is an effective method for surveillance of HIV-1 in women and children, and for early identification of incidence of this infection in women of child-bearing age.

引用

页码：389 / 390

页数：2

共 6 条

[1] Viral levels in newborn African infants undergoing primary HIV-1 infection [J].