Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer

被引：301

作者：

Sarker, Debashis

Reid, Alison H. M.

Yap, Timothy A.

de Bono, Johann S. ^{[1
]}

机构：

[1] Inst Canc Res, Med Sect, Sutton SM2 5PT, Surrey, England

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 15期

基金：

英国医学研究理事会;

关键词：

ANDROGEN RECEPTOR; PTEN EXPRESSION; FISH ANALYSIS; KINASE; AKT; GENE; PROGRESSION; PROTEIN; IDENTIFICATION; INHIBITION;

D O I：

10.1158/1078-0432.CCR-08-0125

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase pathway is increasingly implicated in prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the rapidly evolving therapeutic implications of targeting it. In particular, we highlight the importance of the appropriate selection of agents and combinations, and the critical role of predictive and pharmocodynamic biomarkers.

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收藏

页码：4799 / 4805

页数：7

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