Functional roles of TRPC channels in the developing brain

被引：52

作者：

Tai, Yilin ^{[2
]}

Feng, Shengjie ^{[2
]}

Du, Wanlu ^{[2
]}

Wang, Yizheng ^{[1
]}

机构：

[1] Shanghai Inst Biol Sci, Inst Neurosci, Lab Neural Signal Transduct, Shanghai 200031, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 458卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Neurone; Brain; Development; TRP channels; Synaptic mechanisms; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; CEREBELLAR GRANULE NEURONS; NERVE GROWTH CONES; NEUROTROPHIC FACTOR; CA2+ ENTRY; CALCIUM TRANSIENTS; CELL-PROLIFERATION; DENDRITIC GROWTH; ACTIVATION; PROTEIN;

D O I：

10.1007/s00424-008-0618-y

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels formed by homomeric or heteromeric complexes of TRPC proteins that contain six transmembrane domains. These channels can be activated through a phospholipase-C-dependent mechanism, making them sensors for environmental cues. Their expression begins early in embryonic days and remains in adulthood. These channels have important roles in the processes of neuronal development, including neural stem cell proliferation, cerebellar granule cell survival, axon path finding, neuronal morphogenesis, and synaptogenesis. In this review, we will discuss functional implications of TRPC channels during brain development.

引用

页码：283 / 289

页数：7

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