Corticotropin-releasing factor binding sites in cortex of depressed suicides

被引:37
作者
Hucks, D
Lowther, S
Crompton, MR
Katona, CLE
Horton, RW
机构
[1] UNIV LONDON ST GEORGES HOSP, SCH MED, DEPT PHARMACOL & CLIN PHARMACOL, LONDON SW17 0RE, ENGLAND
[2] UNIV LONDON ST GEORGES HOSP, SCH MED, DEPT FORENS MED, LONDON SW17 0RE, ENGLAND
[3] UCL, SCH MED, DEPT PSYCHIAT, LONDON W1N 8AA, ENGLAND
关键词
corticotropin-releasing factor binding; sites; suicide; depression; post-mortem human brain; antidepressant drugs; frontal cortex; motor cortex;
D O I
10.1007/s002130050439
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Corticotropin-releasing factor (CRF) receptors were measured by saturation binding in frontal and motor cortex of suicides with a firm retrospective diagnosis of depression, and matched controls, The suicides were divided into those who were free of antidepressant drugs, and those in whom prescription of antidepressant drugs was clearly documented. There were no differences in the number or affinity of CRF receptors between antidepressant-free or antidepressant-treated suicides and matched controls in either brain region, When suicides were divided according to violence of death, again there were no differences between violent or non-violent suicides and controls.
引用
收藏
页码:174 / 178
页数:5
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