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Leptin signaling

被引：323
作者：
Ahima, RS [1 ]
Osei, SY [1 ]
机构：
[1] Univ Penn, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA
来源：
PHYSIOLOGY & BEHAVIOR | 2004年 / 81卷 / 02期
关键词：
leptin; obesity; feeding; hypothalamus; neuropeptide;
D O I：
10.1016/j.physbeh.2004.02.014
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems. (C) 2004 Elsevier Inc. All rights reserved.
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页码：223 / 241
页数：19
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