Nutrition and carcinogenesis

被引:8
作者
Collins, AR
Ferguson, LR
机构
[1] Univ Oslo, Dept Nutr, N-0316 Oslo, Norway
[2] Univ Auckland, Fac Med & Hlth Sci, ACSRC Nutr, Auckland, New Zealand
关键词
carcinogen; anticarcinogen; methylation; immunonutrition; nutrigenomics; molecular epidemiology;
D O I
10.1016/j.mrfmmm.2004.05.001
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Traditional views of nutritional carcinogenesis depend on the identification of exogenous carcinogens as major risk factors. As our understanding evolves, it is clear that the pattern of events involves not only exogenous carcinogens, but also metabolic processes and endogenous and exogenous anticarcinogens. The process is modulated by the immune system, and genetics plays a significant role. New monitoring methods provide much-needed tools for providing proof of involvement of various factors at the level of human populations. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 44 条
[31]   The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor [J].
Philpott, M ;
Ching, LM ;
Baguley, BC .
EUROPEAN JOURNAL OF CANCER, 2001, 37 (15) :1930-1937
[32]   Genetic damage and repair in human rectal cells for biomonitoring: sex differences, effects of alcohol exposure, and susceptibilities in comparison to peripheral blood lymphocytes [J].
Pool-Zobel, BL ;
Dornacher, I ;
Lambertz, R ;
Knoll, M ;
Seitz, HK .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 551 (1-2) :127-134
[33]  
Potter J. D., 1997, FOOD NUTR PREVENTION
[34]   Dietary factors and cancer mortality among atomic-bomb survivors [J].
Sauvaget, C ;
Kasagi, F ;
Waldren, CA .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 551 (1-2) :145-152
[35]   Seasonal changes in markers of oxidative damage to lipids and DNA;: correlations with seasonal variation in diet [J].
Smolková, B ;
Dusinska, M ;
Raslová, K ;
McNeill, G ;
Spustova, V ;
Blazícek, P ;
Horská, A ;
Collins, A .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 551 (1-2) :135-144
[36]   Flow cytometric enumeration of micronucleated reticulocytes: High transferability among 14 laboratories [J].
Torous, DK ;
Hall, NE ;
Dertinger, SD ;
Diehl, MS ;
Illi-Love, AH ;
Cederbrant, K ;
Sandelin, K ;
Bolcsfoldi, G ;
Ferguson, LR ;
Pearson, A ;
Majeska, JB ;
Tarca, JP ;
Hewish, DR ;
Doughty, L ;
Fenech, M ;
Weaver, JL ;
Broud, DD ;
Gatehouse, DG ;
Hynes, GM ;
Kwanyuen, P ;
McLean, J ;
McNamee, JP ;
Parenteau, M ;
Van Hoof, V ;
Vanparys, P ;
Lenarczyk, M ;
Siennicka, J ;
Litwinska, B ;
Slowikowska, MG ;
Harbach, PR ;
Johnson, CW ;
Zhao, S ;
Aaron, CS ;
Lynch, AM ;
Marshall, IC ;
Rodgers, B ;
Tometsko, CR .
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2001, 38 (01) :59-68
[37]   Effect of dietary supplementation on the frequency of spontaneous lacZ mutations in the developing colon [J].
Trentin, GA ;
Moody, J ;
Shima, N ;
Thompson, LU ;
Heddle, JA .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 551 (1-2) :223-231
[38]   The influence of dietary flaxseed and other grains, fruits and vegetables on the frequency of spontaneous chromosomal damage in mice [J].
Trentin, GA ;
Moody, J ;
Torous, DK ;
Thompson, LU ;
Heddle, JA .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 551 (1-2) :213-222
[39]   Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks [J].
Turner, PC ;
Nikiema, P ;
Wild, CP .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 1999, 443 (1-2) :81-93
[40]   Assessment of the efficacy of functional food ingredients-introducing the concept "kinetics of biomarkers" [J].
Verhagen, H ;
Coolen, S ;
Duchateau, G ;
Hamer, M ;
Kyle, J ;
Rechner, A .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 551 (1-2) :65-78