Collagen solubility correlates with skin optical clearing

被引：80

作者：

Hirshburg, Jason

Choi, Bernard

Nelson, J. Stuart

Yeh, Alvin T.

机构：

[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

[2] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2006年 / 11卷 / 04期

关键词：

tissues; optical properties; collagen; lasers;

D O I：

10.1117/1.2220527

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations. (c) 2006 Society of Photo-Optical Instrumentation Engineers.

引用

页数：3

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