Collagen solubility correlates with skin optical clearing

被引:80
作者
Hirshburg, Jason
Choi, Bernard
Nelson, J. Stuart
Yeh, Alvin T.
机构
[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA
[2] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA
关键词
tissues; optical properties; collagen; lasers;
D O I
10.1117/1.2220527
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations. (c) 2006 Society of Photo-Optical Instrumentation Engineers.
引用
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页数:3
相关论文
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