Efficient asymmetric hydrogenation of pyridines

被引：195

作者：

Glorius, F ^{[1
]}

Spielkamp, N ^{[1
]}

Holle, S ^{[1
]}

Goddard, R ^{[1
]}

Lehmann, CW ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 21期

关键词：

asymmetric synthesis; chiral auxiliaries; heterogeneous catalysis; hydrogenation; piperidines;

D O I：

10.1002/anie.200453942

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone-substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an additional cleavage step unnecessary.

引用

页码：2850 / 2852

页数：3

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