Diastereoselective heterogeneous catalytic hydrogenation of 2-methyl nicotinic acid using pyroglutamate chiral auxiliary

被引：21

作者：

Douja, N

Malacea, R

Banciu, M

Besson, M

Pinel, C

机构：

[1] Inst Rech Catalyse, CNRS, F-69626 Villeurbanne, France

[2] Univ Politehn Bucharest, Dept Organ Chem, Bucharest, Romania

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 37期

关键词：

diastereoselective; pyridine; optically active piperidine; heterogeneous asymmetric catalysis;

D O I：

10.1016/S0040-4039(03)01794-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoselective hydrogenation of 2-methyl nicotinic acid covalently bound to proline ester or pyroglutamic ester over supported metallic catalyst yielded moderate diastereoselectivity (26%). The hydrogenation of the corresponding pyridinium salt was studied and similar de's were achieved. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6991 / 6993

页数：3

共 14 条

[1]

AHMAN J, 1994, J AM CHEM SOC, V116, P9781

[2]

[Anonymous], PIPERIDINES STRUCTUR

[3] Pyroglutamic acid as a chiral auxiliary in the diastereoselective hydrogenation of disubstituted aromatic rings on Rh(111): a periodic density functional theory approach [J].