Diastereoselective hydrogenation of 2-methylnicotinic acid derivatives with supported metallic catalysts

被引：27

作者：

Douja, N ^{[1
]}

Besson, M ^{[1
]}

Gallezot, P ^{[1
]}

Pinel, C ^{[1
]}

机构：

[1] Inst Rech Catalyse, CNRS, F-69626 Villeurbanne, France

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2002年 / 186卷 / 1-2期

关键词：

diastereoselection; hydrogenation; pyridine; piperidine; catalysts;

D O I：

10.1016/S1381-1169(02)00070-5

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The diastereoselective hydrogenation of 2-methylnicotinic acid covalently bound to different chiral auxiliaries was performed on Pd, Rh and Ru supported catalysts. The cis isomers were formed predominantly with a diastereoselectivity influenced by the structure of the chiral inductor and the nature of the catalyst. The best diastereoselectivity (35%) was obtained when pantolactone was used as chiral auxiliary. (C) 2002 Elsevier Science B.V. All rights reserved.The diastereoselective hydrogenation of 2-methylnicotinic acid covalently bound to different chiral auxiliaries was performed on Pd, Rh and Ru supported catalysts. The cis isomers were formed predominantly with a diastereoselectivity influenced by the structure of the chiral inductor and the nature of the catalyst. The best diastereoselectivity (35%) was obtained when pantolactone was used as chiral auxiliary. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：145 / 151

页数：7

共 20 条

[1] Asymmetric routes to substituted piperidines [J].