Diastereoselective hydrogenations of unsymmetrically substituted aromatics

被引：19

作者：

Exl, C ^{[1
]}

Ferstl, E ^{[1
]}

Honig, H ^{[1
]}

RogiKohlenprath, R ^{[1
]}

机构：

[1] GRAZ UNIV TECHNOL,INST ORGAN CHEM,A-8010 GRAZ,AUSTRIA

来源：

CHIRALITY | 1995年 / 7卷 / 04期

关键词：

prochirality; rhodium; chiral auxiliaries; (-)-menthol; L-proline; chiral cyclohexane derivatives;

D O I：

10.1002/chir.530070406

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Attempts to induce enantioselectivity in the catalytic hydrogenation of unsymmetrically substituted aromatics using covalently bound, well known chiral auxiliaries are described. Marked differences in stereoselectivity and rate of hydrogenolysis are noted as a function of the auxiliary used. Enantioselectivities obtained in the resulting cyclohexyl derivatives are rather poor. (C) 1995 Wiley-Liss, Inc.

引用

页码：211 / 218

页数：8

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