Notch Signaling in Prostate Cancer: A Moving Target

被引：92

作者：

Carvalho, Filipe L. F. ^{[1
]}

Simons, Brian W. ^{[1
,2
]}

Eberhart, Charles G. ^{[1
]}

Berman, David M. ^{[1
,3
,4
,5
,6
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[5] Queens Univ, Dept Pathol & Mol Med, Kingston, ON, Canada

[6] Queens Univ, Canc Res Inst, Canc Biol & Genet Program, Kingston, ON, Canada

来源：

PROSTATE | 2014年 / 74卷 / 09期

关键词：

Notch pathway; tumor progression; prostate cancer; active surveillance; targeted therapy; GAMMA-SECRETASE INHIBITOR; MAMMARY-GLAND DEVELOPMENT; EPITHELIAL STEM-CELL; BREAST-CANCER; BRANCHING MORPHOGENESIS; RADICAL PROSTATECTOMY; GLEASON SCORE; TUMOR-GROWTH; IN-VITRO; PHASE-I;

D O I：

10.1002/pros.22811

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

INTRODUCTIONBy regulating cell fate, proliferation, and survival, Notch pathway signaling provides critical input into differentiation, organization, and function of multiple tissues. Notch signaling is also becoming an increasingly recognized feature in malignancy, including prostate cancer, where it may play oncogenic or tumor suppressive roles. METHODSBased on an electronic literature search from 2000 to 2013 we identified, summarized, and integrated published research on Notch signaling dynamics in prostate homeostasis and prostate cancer. RESULTSIn benign prostate, Notch controls the differentiation state and architecture of the gland. In prostate cancer, similar features correlate with lethal potential and may be influenced by Notch. Increased Notch1 can confer a survival advantage on prostate cancer cells, and levels of Notch family members, such as Jagged2, Notch3, and Hes6 increase with higher cancer grade. However, Notch signaling can also antagonize growth and survival of both benign and malignant prostate cells, possibly through antagonistic effects of the Notch target HEY1 on androgen receptor function. DISCUSSIONNotch signaling can dramatically influence prostate development and disease. Determining the cellular contexts where Notch promotes or suppresses prostate growth could open opportunities for diagnostic and therapeutic interventions. Prostate 74:933-945, 2014. (c) 2014 Wiley Periodicals, Inc.

引用

页码：933 / 945

页数：13

共 104 条

[1]

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas ;

Wheeler, David A. ;

Kinzler, Kenneth W. ;

Myers, Jeffrey N. .

SCIENCE, 2011, 333 (6046) :1154-1157

[2]

Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[3]

NOTCH: THE PAST, THE PRESENT, AND THE FUTURE [J].

Artayanis-Tsakonas, Spyros ;

Muskavitch, Marc A. T. .

NOTCH SIGNALING, 2010, 92 :1-29

[4]

ANDROGEN RECEPTOR GENE-MUTATIONS IDENTIFIED BY SSCP IN 14 SUBJECTS WITH ANDROGEN INSENSITIVITY SYNDROME [J].

BATCH, JA ;

WILLIAMS, DM ;

DAVIES, HR ;

BROWN, BD ;

EVANS, BAJ ;

HUGHES, IA ;

PATTERSON, MN .

HUMAN MOLECULAR GENETICS, 1992, 1 (07) :497-503

[5]

Tissue repair and stem cell renewal in carcinogenesis [J].

Beachy, PA ;

Karhadkar, SS ;

Berman, DM .

NATURE, 2004, 432 (7015) :324-331

[6]

Hey1, a mediator of notch signaling, is an androgen receptor corepressor [J].

Belandia, B ;

Powell, SM ;

García-Pedrero, JM ;

Walker, MM ;

Bevan, CL ;

Parker, MG .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (04) :1425-1436

[7]

Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[8]

Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator [J].

Bin Hafeez, Bilal ;

Adhami, Vaqar Mustafa ;

Asim, Mohammad ;

Siddiqui, Imtiaz A. ;

Bhat, Kumar M. ;

Zhong, Weixiong ;

Saleem, Mohammad ;

Din, Maria ;

Setaluri, Vijayasaradhi ;

Mukhtar, Hasan .

CLINICAL CANCER RESEARCH, 2009, 15 (02) :452-459

[9]

In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells [J].

Blackwood, John K. ;

Williamson, Stuart C. ;

Greaves, Laura C. ;

Wilson, Laura ;

Rigas, Anastasia C. ;

Sandher, Raveen ;

Pickard, Robert S. ;

Robson, Craig N. ;

Tumbull, Douglass M. ;

Taylor, Robert W. ;

Heer, Rakesh .

JOURNAL OF PATHOLOGY, 2011, 225 (02) :181-188

[10]

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer [J].

Carver, Brett S. ;

Chapinski, Caren ;

Wongvipat, John ;

Hieronymus, Haley ;

Chen, Yu ;

Chandarlapaty, Sarat ;

Arora, Vivek K. ;

Le, Carl ;

Koutcher, Jason ;

Scher, Howard ;

Scardino, Peter T. ;

Rosen, Neal ;

Sawyers, Charles L. .

CANCER CELL, 2011, 19 (05) :575-586

← 1 2 3 4 5 6 7 8 9 10 →