The Notch and Sonic hedgehog signalling pathways in immunity

被引：31

作者：

Benson, RA ^{[1
]}

Lowrey, JA ^{[1
]}

Lamb, JR ^{[1
]}

Howie, SEM ^{[1
]}

机构：

[1] Univ Edinburgh, Immunobiol Grp, MRC, Ctr Inflammat Res,Coll Med & Vet Med, Edinburgh EH8 9AG, Midlothian, Scotland

来源：

MOLECULAR IMMUNOLOGY | 2004年 / 41卷 / 6-7期

关键词：

Notch; Sonic hedgehog; CD4+ T cells; cytokines; thymocytes;

D O I：

10.1016/j.molimm.2004.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4(+) T lymphocytes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：715 / 725

页数：11

共 89 条

[1]

ABARON M, 2003, SEMIN CELL DEV BIOL, V14, P113

[2] Notch signaling augments T cell responsiveness by enhancing CD25 expression [J].

Adler, SH ;

Chiffoleau, E ;

Xu, LW ;

Dalton, NM ;

Burg, JM ;

Wells, AD ;

Wolfe, MS ;

Turka, LA ;

Pear, WS .

JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :2896-2903

[3] Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes [J].

Anastasi, E ;

Campese, AF ;

Bellavia, D ;

Bulotta, A ;

Balestri, A ;

Pascucci, M ;

Checquolo, S ;

Gradini, R ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Di Mario, U ;

Screpanti, I .

JOURNAL OF IMMUNOLOGY, 2003, 171 (09) :4504-4511

[4] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[5] Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice [J].

Bellavia, D ;

Campese, AF ;

Alesse, E ;

Vacca, A ;

Felli, MP ;

Balestri, A ;

Stoppacciaro, A ;

Tiveron, C ;

Tatangelo, L ;

Giovarelli, M ;

Gaetano, C ;

Ruco, L ;

Hoffman, ES ;

Hayday, AC ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Screpanti, I .

EMBO JOURNAL, 2000, 19 (13) :3337-3348

[6]

Bellusci S, 1997, DEVELOPMENT, V124, P53

[7] Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J].

Bhardwaj, G ;

Murdoch, B ;

Wu, D ;

Baker, DP ;

Williams, KP ;

Chadwick, K ;

Ling, LE ;

Karanu, FN ;

Bhatia, M .

NATURE IMMUNOLOGY, 2001, 2 (02) :172-180

[8] Notch pathway: Making sense of suppressor of hairless [J].

Bray, S ;

Furriols, M .

CURRENT BIOLOGY, 2001, 11 (06) :R217-R221

[9] The immunological synapse [J].

Bromley, SK ;

Burack, WR ;

Johnson, KG ;

Somersalo, K ;

Sims, TN ;

Sumen, C ;

Davis, MM ;

Shaw, AS ;

Allen, PM ;

Dustin, ML .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :375-396

[10] A novel proteolytic cleavage involved in Notch signaling:: The role of the disintegrin-metalloprotease TACE [J].

Brou, C ;

Logeat, F ;

Gupta, N ;

Bessia, C ;

LeBail, O ;

Doedens, JR ;

Cumano, A ;

Roux, P ;

Black, RA ;

Israël, A .

MOLECULAR CELL, 2000, 5 (02) :207-216

← 1 2 3 4 5 6 7 8 9 →