Cobalt-mediated cyclotrimerization and cycloisomerization reactions. Synthetic applications

被引：33

作者：

Aubert, C ^{[1
]}

Buisine, O ^{[1
]}

Petit, M ^{[1
]}

Slowinski, F ^{[1
]}

Malacria, M ^{[1
]}

机构：

[1] Univ Paris 06, Lab Chim Organ & Organ Synth, F-75252 Paris 05, France

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 08期

关键词：

D O I：

10.1351/pac199971081463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article reviews our contribution in the field of the cobalt(I)-mediated cyclizations. The use of new unsaturated partners such as allenes extend the scope and the utility of the previously developed intramolecular [2+2+2] cyclotrimerization. The presence of chiral auxiliaries induced high level of diastereoselectivity in the enediynes cyclization. The discovery of cobalt(I) catalyzed ene-type reaction allows to propose an efficient route to the basic skeleton of tetracyclic diterpenes via a one-pot sequence of cyclizations: [ene-type]/ [2+2+2]/[4+2]. This cascade created six carbon-carbon bonds, four rings in a totally stereoselective manner. Finally, a new strategy to the taxoids is proposed.

引用

页码：1463 / 1470

页数：8

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