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RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus

被引：15
作者：
Asami, Yukihiro
Kakeya, Hideaki
Okada, Gen
Toi, Masakazu
Osada, Hiroyuki
机构：
[1] RIKEN, Antibiot Lab, DRI, Wako, Saitama 3510198, Japan
[2] RIKEN, BioResource Ctr, Japan Collect Microorganisms, Microbe Div, Wako, Saitama 3510198, Japan
[3] Tokyo Metropolitan Komagome Hosp, Bunkyo Ku, Tokyo 1138677, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2006年 / 59卷 / 11期
关键词：
angiogenesis inhibitor; RK-95113; endothelial cells; migration; vascular endothelial growth factor (VEGF); Aspergillus fumigatus;
D O I：
10.1038/ja.2006.97
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We found that the strain Aspergillus fumigatus var. fumigatus RK95-113 produced a new angiogenesis inhibitor, RK-95113. Spectroscopic analyses identified the structure of RK-95113 as a new fumagillin-related small molecule. RK-95113 preferentially inhibited the growth of human umbilical vein endothelial cells (HUVECs) rather than that of human normal fibroblasts in cell proliferation assays and blocked endothlial cell migration induced by vascular endothelial growth factor (VEGF).
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页码：724 / 728
页数：5
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