Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins

被引：59

作者：

Hitt, R ^{[1
]}

Wolf, DH ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Biochem, D-70569 Stuttgart, Germany

来源：

FEMS YEAST RESEARCH | 2004年 / 4卷 / 07期

关键词：

ERAD; protein quality control; Der1p; Der1-like proteins;

D O I：

10.1016/j.femsyr.2004.02.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The endoplasmic reticulum (ER) contains a highly effective protein quality control system eliminating malfolded proteins by a mechanism called ER-associated protein degradation (ERAD). Here, we unravel the topology of Der1p, a previously identified component of the ERAD system. Der1p contains four transmembrane domains, its N- and C-terminus protrude into the cytoplasm and contribute to its function. Additionally, we describe a yeast homologue of Der1p, Dfm1p, which does not seem to be involved in ERAD. In contrast, a Caenorhabditis elegans orthologue of Der1p, R151.6, is capable of complementing der1-defective phenotypes in yeast. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：721 / 729

页数：9

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